• Meta-analysis
  • Treatment: Physical Modalities
Clinical RelevanceDOI 4 min read
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Patient-friendly summary

If you read nothing else

Extracorporeal shock wave therapy (ESWT) is more effective at reducing myofascial pain syndrome (MPS) pain compared to other methods.

Bottom line

ESWT shows promise for treating myofascial pain and is worth discussing with your provider.

Moderate evidence

Ask your provider

  • What are the benefits and risks of ESWT for my condition?
  • How many sessions would I need, and how long are they?
  • What can I expect the recovery to be like after ESWT?

Try this week

  • Ask your provider about ESWT as a possible treatment for myofascial pain.

How well it works

7.0 / 10

ESWT was found to be more effective than other treatments in reducing pain and disability index in patients with MPS.

Moderate evidence

Words decoded

Myofascial pain syndrome (MPS)
— A type of muscle pain caused by trigger points that can cause pain in one area or all over the body.
Extracorporeal shock wave therapy (ESWT)
— A treatment that uses high-energy sound waves to help break up muscle knots and reduce pain.
Trigger points
— Sensitive spots in the muscles that, when pressed, can cause pain in other areas of the body.

Full research — for clinicians and curious readers

Study Summary

Background

Myofascial pain syndrome (MPS) is a common musculoskeletal condition characterized by painful trigger points in muscles that cause local and referred pain. Traditional treatments include trigger point injections, dry needling, electrical stimulation, and ultrasound therapy. Extracorporeal shock wave therapy (ESWT) has emerged as a non-invasive physical therapy option that uses high-energy mechanical waves to treat various musculoskeletal conditions. While individual studies have shown promise for ESWT in treating MPS, there has been limited systematic evaluation of its effectiveness compared to other established treatments.

What They Did

The researchers conducted a comprehensive systematic review and meta-analysis by searching major medical databases (PubMed, Embase, Cochrane, Web of Science) through October 2021. They included 8 controlled clinical studies involving 571 patients with myofascial pain syndrome. Most patients (541) had neck and upper back pain, while 30 had lower back pain. The studies compared ESWT to various control treatments including trigger point injection, dry needling, ultrasound therapy, electrical stimulation, and kinesiology taping.

They assessed study quality using the PEDro scale and analyzed outcomes including pain intensity (Visual Analog Scale), pressure pain threshold, and neck disability index. Statistical analysis was performed using RevMan 5.4 software with appropriate tests for heterogeneity.

What They Found

The meta-analysis revealed significant benefits for ESWT compared to other treatments. Pain levels after ESWT were substantially lower than other treatments (mean difference = -1.34 on VAS scale, 95% CI: -1.87 to -0.81, P<0.00001). Pressure pain threshold, which measures how much pressure is needed to cause pain, was higher after ESWT treatment (mean difference = 0.90, 95% CI: 0.73 to 1.07, P<0.00001), indicating less sensitivity to pressure. The neck disability index, measuring functional impairment, was also significantly lower after ESWT (mean difference = -1.79, 95% CI: -2.48 to -1.10, P<0.00001).

All results showed strong statistical significance, though there was heterogeneity between studies due to different patient characteristics and treatment protocols.

What This Means

This meta-analysis provides strong evidence that ESWT is more effective than several established treatments for myofascial pain syndrome. The therapy offers significant advantages as a non-invasive option that avoids the potential complications and patient tolerance issues associated with injections or needling procedures. For patients with neck, shoulder, and upper back trigger points, ESWT appears to provide meaningful pain relief and functional improvement. Clinicians can consider ESWT as a first-line treatment option, particularly for patients who prefer non-invasive approaches or have concerns about needling procedures.

The therapy's ability to improve both pain and function makes it a valuable addition to the treatment arsenal for myofascial pain syndrome.

78/100
Evidence StrengthStrong
Study Quality
Sample Size
Replication
Total Patients Analyzed
571
Statistical Significance
p<0.00001
Studies Included
8

Results Comparison

Pain Reduction (VAS Scale)

points lower
ESWT1.34 points lower
Other Treatments0 points lower

Key Findings

FindingDetailImpact
ESWT significantly reduced pain compared to all other treatmentsMean difference of -1.34 points on VAS scale (95% CI: -1.87 to -0.81, P<0.00001)High
Pressure pain threshold improved more with ESWTMean difference of 0.90 (95% CI: 0.73 to 1.07, P<0.00001), indicating less pain sensitivityHigh
Functional disability improved significantly with ESWTNeck Disability Index was 1.79 points lower (95% CI: -2.48 to -1.10, P<0.00001)High
Benefits were consistent across different control treatmentsESWT showed superiority over trigger point injection, dry needling, ultrasound, and TENSMedium
Most evidence focused on neck and upper back pain541 of 571 patients had cervical/upper back MPS, with limited data on other regionsMedium
Study Methodology
Study Design
Systematic review and meta-analysis of controlled clinical trials
Sample Size
571
Duration
Studies ranged from 4-6 weeks treatment duration
Population
Adults with diagnosed myofascial pain syndrome and trigger points
Outcome Measures
Visual Analog Scale for pain · Pressure pain threshold · Neck Disability Index

Strengths

  • Comprehensive search of multiple major databases
  • Used rigorous statistical methods with appropriate heterogeneity testing
  • Included only controlled clinical trials for higher evidence quality
  • Assessed multiple clinically relevant outcome measures

Limitations

  • High heterogeneity between studies due to different protocols and populations
  • Limited evidence for body regions other than neck and upper back
  • Some included studies had methodological concerns with randomization and blinding
  • Short follow-up periods in most studies (4-6 weeks)

Key Takeaways for Patients

What This Means for You

  1. ESWT appears to be more effective than traditional treatments for trigger point pain in the neck and shoulders

  2. This treatment doesn't require needles or injections, making it a good option if you're uncomfortable with invasive procedures

  3. You may experience significant pain relief and better function within 4-6 weeks of treatment

  4. The treatment appears to be safe with no major side effects reported in the studies

  5. Talk to your healthcare provider about whether ESWT is available and appropriate for your specific condition

Read the Full Paper

Access the complete peer-reviewed study from Annals of Translational Medicine

View Full Study

Related Research

●●●●● LandmarkSystematic Review

The State of Extracorporeal Shockwave Therapy for Myofascial Pain Syndrome—A Scoping Review and a Call for Standardized Protocols

Müller-Ehrenberg et al.·Life·2025

This scoping review identifies significant methodological inconsistencies in ESWT research for myofascial pain syndrome. Despite evidence suggesting effectiveness, poor study standardization prevents definitive conclusions about therapeutic potential.

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●●●●● LandmarkSystematic Review

Effectiveness of Photobiomodulation Therapy in the Treatment of Myofascial Pain Syndrome of the Upper Trapezius Muscle: A Systematic Review and Meta-Analysis

Alayat et al.·Photobiomodulation, Photomedicine, and Laser Surgery·2022

This systematic review of 17 studies with 944 patients found that photobiomodulation therapy effectively reduces pain in myofascial trigger points of the upper trapezius muscle. When combined with exercise, the therapy showed large effect sizes for both pain reduction and improved pressure pain thre

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●●●●○ StrongRandomized Controlled Trial

Comparison of extracorporeal shock wave therapy and manual therapy on active trigger points of the sternocleidomastoid muscle in cervicogenic headache: A randomized controlled trial

Xia et al.·Turkish Journal of Physical Medicine and Rehabilitation·2025

ESWT and manual therapy were equally effective for active SCM trigger points in cervicogenic headache, with both showing significant pain reduction and improved function sustained at 4-week follow-up.

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●●●●○ StrongRandomized Controlled Trial

Immediate efficacy of low-intensity focused ultrasound versus planar ultrasound in patients with myofascial pain syndrome of upper trapezius: a randomized controlled clinical trial

Chen et al.·BMC Musculoskeletal Disorders·2025

Both low-intensity focused ultrasound and low-intensity planar ultrasound provided significant immediate pain relief in upper trapezius myofascial pain syndrome, with no statistically significant difference between the two modalities.

Physical ModalitiesRead →