Cohort StudyTreatment: Trigger Point InjectionClinical RelevanceDOI
7 min read
Jump to:
Full research — for clinicians and curious readers

Study Summary

Background

Myofascial pain syndrome (MPS) is an extremely common condition that affects up to 85% of adults at some point in their lives and is a leading cause of neck and back pain complaints seen in emergency departments. Despite how frequently patients present with this problem, conventional treatments often fall short. Standard approaches like oral pain medications and traditional trigger point injections typically provide only temporary relief and may not address the underlying source of pain. Emerging research has increasingly pointed to fascia—the connective tissue surrounding muscles—as a key driver of pain in MPS, rather than muscle tissue alone.

This shift in understanding has opened the door to new treatment approaches that target the fascial planes between muscles rather than injecting directly into muscle. Given these developments and the growing use of ultrasound-guided procedures in emergency medicine, the researchers developed a novel technique called the paravertebral fascial plane block (PFPB) to specifically target these fascial structures in patients with difficult-to-treat paraspinal pain.

What They Did

The researchers conducted a retrospective observational study at a single academic medical center, reviewing all patients who received the PFPB procedure over a one-year period from September 2024 to August 2025. They included adult emergency department patients who had paraspinal pain consistent with myofascial pain syndrome and who either had not responded adequately to standard emergency department pain medications or had a documented history of recurrent, hard-to-treat paraspinal MPS. The PFPB procedure had two main parts: first, injection of a combination of local anesthetic (bupivacaine), normal saline, and sometimes dexamethasone into the fascial plane between the superficial back muscles and the deeper erector spinae muscle; and second, deliberate needling of the fascial layers under ultrasound guidance. The treating physician used ultrasound to visualize the exact anatomical plane and performed 10 or more needle passes through the fascia.

Pain scores were collected as part of routine clinical care at three time points: before the procedure, at emergency department discharge, and 24-48 hours later via telephone follow-up. The researchers then analyzed these scores to see how much pain relief patients experienced.

What They Found

Eleven patients underwent the PFPB procedure during the study period. The group had a median age of 48 years and was 64% female. The majority of patients (73%) had first tried standard emergency department medications without adequate relief, while the remaining 27% had known refractory MPS and went straight to the procedure. The PFPB was performed at various spinal levels: cervical in 2 patients, thoracic in 4 patients, and lumbar in 5 patients.

Five patients (45%) received bilateral blocks.

The pain reduction was substantial and rapid. The median pain score on the 0-10 Numeric Rating Scale was 9 out of 10 before the procedure, which dropped significantly to 3 out of 10 at emergency department discharge—a 67% relative reduction. This improvement was statistically significant with a p-value of 0.004. At 24-48 hour follow-up, which 10 of 11 patients completed, the median pain score had fallen further to 1 out of 10, representing an 89% reduction from the original baseline (p=0.006).

Importantly, 80% of patients with follow-up data reported either further improvement or sustained relief compared to their discharge pain levels. Only 20% reported mild recurrence of pain, though even these patients remained below their original baseline pain levels. The difference between discharge and follow-up scores was not statistically significant (p=0.265), suggesting the initial relief was maintained rather than fading.

No procedural complications or adverse events occurred in any patient. None of the treated patients returned to any emergency department in the health system within 48 hours of discharge.

What This Means

These findings suggest that the paravertebral fascial plane block may be a promising new option for patients with severe, refractory paraspinal myofascial pain syndrome in the emergency department setting. The procedure appeared to provide both rapid and sustained pain relief, with most patients experiencing dramatic improvement that lasted at least 24-48 hours. The absence of any complications in this initial series, combined with the superficial needle approach under direct ultrasound visualization, suggests a favorable safety profile compared to deeper injection techniques that carry risks like pneumothorax.

For patients, this represents a potential alternative when standard medications fail to provide adequate relief, or when they have recurrent episodes that have been difficult to manage. The procedure specifically targets fascial tissue rather than muscle, which aligns with newer understanding of how MPS generates pain. For clinicians, particularly emergency physicians with ultrasound training, the PFPB offers a reproducible technique that can be applied across all spinal levels using consistent anatomical landmarks.

However, the researchers appropriately caution that these are preliminary findings from a small, single-center retrospective study without a control group. The small sample size of 11 patients limits statistical power and prevents subgroup analyses. Because the procedure combines multiple elements—saline hydrodissection, anesthetic injection, fascial needling, and sometimes steroid—it remains unclear which components contribute most to the observed benefit. Patients also received varying combinations of pre-procedure medications, making it impossible to completely separate the PFPB effect from other treatments.

The 24-48 hour follow-up window is too short to assess longer-term durability or recurrence patterns. Larger, prospective, controlled studies will be needed to validate these encouraging initial results and determine the precise role of this technique in emergency pain management.

25/100
Evidence StrengthLimited
Study Quality
Sample Size
Replication
9/10
Median Pre-Block Pain Score
3/10
Median Pain Score at ED Discharge
1/10
Median Pain Score at 24-48h Follow-up
p=0.004
Statistical Significance Pre-Block to Discharge

Results Comparison

Median NRS Pain Score (0-10)

NRS
Pre-Block9 NRS
ED Discharge3 NRS
24-48h Follow-up1 NRS

Key Findings

Dramatic and statistically significant pain reduction immediately after PFPBHigh

Median NRS pain score decreased from 9/10 (IQR 8-9) pre-block to 3/10 (IQR 0-4) at ED discharge, a 67% relative reduction (p=0.004)

Sustained pain relief at short-term follow-upHigh

At 24-48 hours, median pain score was 1/10 (IQR 0-2.75), representing 89% reduction from baseline (p=0.006); 80% of patients reported sustained or improved relief

No complications or adverse eventsHigh

No procedural complications occurred, and no patients returned to any ED in the health system within 48 hours of initial discharge

Procedure feasible across all spinal levelsMedium

PFPB was successfully performed at cervical (18%), thoracic (36%), and lumbar (45%) levels, with bilateral blocks in 45% of patients

Heterogeneous injectate composition limits component analysisMedium

Patients received varying combinations of bupivacaine, normal saline, and dexamethasone; optimal mixture remains unknown

Study Methodology
Study Design
Single-center retrospective observational cohort study
Sample Size
11
Duration
September 1, 2024 – August 31, 2025; follow-up at 24-48 hours
Population
Adult ED patients with paraspinal MPS refractory to standard analgesics or with history of recurrent intractable paraspinal MPS
Outcome Measures
Numeric Rating Scale (NRS) pain scores at pre-block, ED discharge, and 24-48h telephone follow-up · ED bounceback within 48 hours · Procedural complications and adverse events

Strengths

  • Novel technique targeting fascia rather than muscle aligns with emerging pain science
  • Comprehensive safety monitoring with no complications observed
  • Multi-level applicability (cervical, thoracic, lumbar) with reproducible anatomy
  • Prospective collection of pain scores during routine clinical care reduces recall bias

Limitations

  • Very small sample size (n=11) severely limits generalizability and statistical power
  • Retrospective observational design without control group cannot establish causality
  • Heterogeneous injectate composition precludes determining optimal mixture or which components drive benefit
  • Short follow-up period (24-48 hours) cannot assess durability or long-term recurrence
  • Single-center study with fellowship-trained physicians limits generalizability to other practice settings

Key Takeaways for Patients

What This Means for You

  1. 01A new ultrasound-guided injection technique targeting the tissue between back muscles showed dramatic pain relief for patients with severe, hard-to-treat back and neck pain in the emergency department
  2. 02Pain scores dropped from an average of 9 out of 10 to 1 out of 10 within 1-2 days, and no complications occurred
  3. 03This is still early research with only 11 patients, so larger studies are needed to confirm these promising results
  4. 04The procedure is not yet widely available and requires specialized ultrasound training; ask your doctor about options for refractory myofascial pain
  5. 05Standard treatments like medications and physical therapy remain first-line options; this approach is for cases that don't respond to usual care

Read the Full Paper

Access the complete peer-reviewed study from American Journal of Emergency Medicine

View Full Study

Related Research

●●●●● LandmarkMeta-analysis

Trigger Point Injections Versus Medical Management for Acute Myofascial Pain: A Systematic Review and Meta-Analysis

Haroutiun Hamzoian & Vahe Zograbyan·Cureus·2023

A meta-analysis of four RCTs found that trigger point injections significantly reduced acute myofascial pain compared with medical management alone (SMD -2.09; 95% CI -3.34 to -0.85; P = 0.001), though the authors flag notable heterogeneity and bias concerns.

Trigger Point InjectionRead →
●●●●● LandmarkMeta-analysis

Local Anesthetic Injections for the Short-Term Treatment of Head and Neck Myofascial Pain Syndrome: A Systematic Review with Meta-Analysis

Nouged et al.·Journal of Oral & Facial Pain and Headache·2019

Systematic review of 884 patients found local anesthetic trigger point injections showed only modest benefits over dry needling for head and neck myofascial pain. Benefits disappeared when only high-quality studies were analyzed, suggesting bias may explain apparent advantages.

Trigger Point InjectionRead →
●●●●● LandmarkNarrative Review

Treatment of Myofascial Pain Syndrome

Hong, Chang-Zern·Current Pain and Headache Reports·2006

Comprehensive review establishing that successful myofascial pain treatment requires addressing underlying causes before trigger point therapy. Multiple treatment modalities are effective, but lasting relief depends on treating root pathology and patient education.

Trigger Point InjectionRead →
●●●●○ StrongCase Report/Series

The paravertebral fascial plane block: A novel, ultrasound-guided technique for paraspinal neck and back pain

Aulia et al.·American Journal of Emergency Medicine·2026

A novel ultrasound-guided fascial injection technique provided rapid, sustained pain relief for 11 emergency department patients with refractory paraspinal myofascial pain. Pain scores dropped from 9/10 to 1/10 at 48-hour follow-up with no complications.

Trigger Point InjectionRead →