Case Report/SeriesTreatment: Trigger Point InjectionClinical RelevanceDOI
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Patient-friendly summary

If you read nothing else

A new method called the paravertebral fascial plane block (PFPB) helps reduce neck and back pain from a condition called myofascial pain syndrome (MPS).

Bottom line

This treatment seems promising for pain relief and is worth discussing with your provider.

Preliminary evidence

Ask your provider

  • What are my options for treating my paraspinal MPS?
  • Could the PFPB be a good choice for me?
  • What are the potential benefits and risks of the PFPB?

Try this week

  • Ask your doctor about the PFPB if you have persistent MPS pain.
  • Keep track of your pain levels before and after trying new treatments.

How well it works

8.0 / 10

The PFPB showed significant pain reduction in a small case series.

Preliminary

NRS 0–10

19

Pain reduced from 9 to 1

Full research — for clinicians and curious readers

Study Summary

Background

Myofascial pain syndrome (MPS) affecting the paraspinal muscles is a common reason for emergency department visits, but existing treatments often provide incomplete or short-lived relief. Traditional approaches like oral pain medications and trigger point injections frequently fail to address the underlying problem. Recent research suggests that fascia (connective tissue surrounding muscles) plays a more important role in pain generation than muscle tissue alone. The fascia contains numerous pain receptors and may become thickened, scarred, or stuck together in people with chronic pain.

This understanding has led researchers to develop treatments that specifically target fascial tissue rather than just muscle.

What They Did

Emergency medicine physicians at the University of Pennsylvania developed a new ultrasound-guided procedure called the paravertebral fascial plane block (PFPB). This technique combines several elements: injection of local anesthetic (bupivacaine) mixed with saline and sometimes steroid medication into the space between muscle layers, followed by controlled needling of the fascial tissue under ultrasound guidance. They tested this approach on 11 adult patients who came to the emergency department with severe paraspinal muscle pain that hadn't responded adequately to standard pain medications. The researchers measured pain scores before the procedure, at hospital discharge, and 24-48 hours later by phone follow-up.

They performed the procedure at different spinal levels (neck, mid-back, and lower back) depending on where patients had the most pain.

What They Found

All 11 patients experienced dramatic pain reduction. Before the procedure, patients rated their pain as 9 out of 10 on average. Immediately after the procedure at discharge, pain scores dropped to 3 out of 10 - a 67% reduction. At follow-up 24-48 hours later, pain scores were even lower at 1 out of 10 - an 89% reduction from baseline.

Eight out of 10 patients with follow-up data (80%) reported their pain relief was either sustained or had improved further since leaving the hospital. No complications occurred, and none of the treated patients returned to any emergency department in their health system within 48 hours.

What This Means

This study suggests that targeting fascial tissue rather than muscle alone may be a more effective approach for treating stubborn paraspinal pain. The PFPB technique appears to provide both immediate and sustained pain relief for patients whose pain hasn't responded to conventional treatments. Because the procedure uses ultrasound guidance and stays in superficial tissue planes, it may be safer than deeper injection techniques. However, this was a small study without a control group, so larger controlled trials are needed to confirm these promising results and determine exactly which components of the procedure are most important for pain relief.

25/100
Evidence StrengthLimited
Study Quality
Sample Size
Replication
89%
Pain Reduction at Follow-up
9→1
Pain Score Change (0-10)
0%
Complication Rate

Results Comparison

NRS Pain Score (0-10)

points
Pre-Block9 points
Discharge3 points
Follow-up1 points

Key Findings

Dramatic immediate pain reduction with PFPB procedureHigh

Median pain scores decreased from 9/10 to 3/10 at discharge (67% reduction, p=0.004)

Sustained pain relief at short-term follow-upHigh

Pain scores further improved to 1/10 at 24-48 hours (89% total reduction, p=0.006)

Excellent safety profile with no complicationsMedium

No procedural adverse events and no emergency department returns within 48 hours

Technique applicable across all spinal levelsMedium

Successfully performed at cervical (18%), thoracic (36%), and lumbar (45%) levels

Majority experienced sustained or improved reliefHigh

80% of patients (8/10) reported maintained or further improved pain at follow-up

Study Methodology
Study Design
Single-center retrospective observational case series
Sample Size
11
Duration
September 2024 to August 2025, with 24-48 hour follow-up
Population
Adult ED patients with refractory paraspinal myofascial pain syndrome
Outcome Measures
Numeric Rating Scale (NRS) pain scores · Adverse events · Emergency department returns

Strengths

  • Novel technique addressing fascial pain mechanisms
  • Consistent dramatic pain reduction across all patients
  • No complications or adverse events reported
  • Technique applicable across multiple spinal levels

Limitations

  • Very small sample size (11 patients) limits generalizability
  • No control group to compare effectiveness against standard care
  • Short follow-up period (24-48 hours) - no long-term data
  • Single-center study with fellowship-trained physicians may not reflect broader applicability

Key Takeaways for Patients

What This Means for You

  1. 01A new ultrasound-guided injection technique targeting tissue around the spine muscles shows promise for stubborn back and neck pain
  2. 02The procedure appears safe with no complications reported in this small study
  3. 03Pain relief was dramatic and sustained for at least 2 days after treatment
  4. 04This approach may help patients whose pain hasn't responded to standard medications
  5. 05Larger studies are needed to confirm these promising early results

Read the Full Paper

Access the complete peer-reviewed study from American Journal of Emergency Medicine

View Full Study

Related Research

●●●●● LandmarkMeta-analysis

Trigger Point Injections Versus Medical Management for Acute Myofascial Pain: A Systematic Review and Meta-Analysis

Haroutiun Hamzoian & Vahe Zograbyan·Cureus·2023

A meta-analysis of four RCTs found that trigger point injections significantly reduced acute myofascial pain compared with medical management alone (SMD -2.09; 95% CI -3.34 to -0.85; P = 0.001), though the authors flag notable heterogeneity and bias concerns.

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●●●●● LandmarkMeta-analysis

Local Anesthetic Injections for the Short-Term Treatment of Head and Neck Myofascial Pain Syndrome: A Systematic Review with Meta-Analysis

Nouged et al.·Journal of Oral & Facial Pain and Headache·2019

Systematic review of 884 patients found local anesthetic trigger point injections showed only modest benefits over dry needling for head and neck myofascial pain. Benefits disappeared when only high-quality studies were analyzed, suggesting bias may explain apparent advantages.

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●●●●● LandmarkNarrative Review

Treatment of Myofascial Pain Syndrome

Hong, Chang-Zern·Current Pain and Headache Reports·2006

Comprehensive review establishing that successful myofascial pain treatment requires addressing underlying causes before trigger point therapy. Multiple treatment modalities are effective, but lasting relief depends on treating root pathology and patient education.

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●●●●○ StrongNarrative Review

Integrating Ultrasound-Guided Injections and Peripheral Magnetic Stimulation in Chronic Myofascial/Lumbar Pain

Wu et al.·Life·2025

This perspective article proposes combining ultrasound-guided multifidus injections with repetitive peripheral magnetic stimulation as a multimodal approach for chronic myofascial and lumbar pain. Preliminary findings from a pilot study of three patients suggest significant pain and disability reduction after 12 combined treatment sessions.

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