Cross-Sectional StudyComorbidities & Related ConditionsClinical RelevanceDOI
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Patient-friendly summary

If you read nothing else

This study found that people with temporomandibular joint disorder feel pain in many parts of their body, not just their jaw.

Bottom line

This study shows that people with temporomandibular joint disorder experience pain in many areas of the body, not just the jaw.

Moderate evidence

Study participants

n=5023.36 ± 2.14 years37 women and 13 men

generally healthy people with complete natural dentition

Words decoded

myofascial pain
— pain in muscles that is felt in a specific area and can sometimes spread to other areas.
referred pain
— pain that is felt in a part of the body other than where the problem started.
temporomandibular joint
— the joint where your jawbone connects to the rest of your skull, often简称 TMJ.

Myth vs fact

Myth: Temporomandibular joint disorder only causes pain in the jaw.
Fact: People with this disorder can experience pain in many areas of the body.

You're not alone

“It's common to have pain in several areas when you have temporomandibular joint disorder.”

Full research — for clinicians and curious readers

Study Summary

Background

Temporomandibular joint disorders (TMJ-D) affect 10-15% of the population, with women affected twice as often as men. The most common type is myalgia, characterized by headache, referred pain, and restricted jaw movement. Patients with myofascial pain with referral often have complex pain patterns that extend beyond the jaw area. Understanding the distribution of pain throughout the body is crucial for proper diagnosis and treatment planning.

This study addressed the need to better characterize the widespread nature of pain in patients with TMJ myofascial pain with referral.

What They Did

Researchers examined 50 healthy adults (37 women, 13 men) with complete natural teeth, average age 23.36 years, who had jaw pain of at least 8/10 on a visual analog scale. All participants underwent comprehensive clinical examination using standardized Diagnostic Criteria for Temporomandibular Disorders (DC/TMD) protocols. The researchers used the TMD Pain Screener to assess dysfunction severity and the Graded Chronic Pain Scale to evaluate pain impact. Most importantly, they had patients complete detailed body chart drawings, marking all areas of pain throughout their bodies using dots for localized pain and arrows for radiating pain patterns.

Statistical analysis compared pain locations between men and women.

What They Found

The study revealed remarkably widespread pain patterns. Participants identified 40 different body areas affected by pain. Only six subjects reported pain in 2-3 isolated locations, while one person marked 17 different painful areas. An overwhelming 88% (44 people) reported pain in at least four different body regions.

The most common pain locations were the right masseter muscle (70%), left masseter muscle (68%), and left TMJ (68%), with right TMJ affected in 54%. Cervical spine problems were reported by 56% of participants. Significantly more men than women experienced right masseter muscle pain (92.3% vs 62.2%) and right TMJ pain (84.6% vs 43.2%). Using the chronic pain scale, 60% had low-intensity pain with low disability, 12% had high-intensity pain with low disability, 12% had high disability with moderate limitation, and 10% had severe functional limitation.

What This Means

This study reveals that TMJ myofascial pain with referral is not a localized condition but rather a widespread pain syndrome affecting multiple body regions. The extensive pain mapping suggests that central sensitization processes may be involved, where the nervous system becomes hypersensitive and amplifies pain signals throughout the body. For clinicians, this means that treating only the jaw may be insufficient—a comprehensive approach addressing postural issues, cervical spine problems, and the biopsychosocial aspects of chronic pain may be necessary. The high prevalence of cervical spine involvement (56%) suggests that TMJ disorders and neck problems are closely linked, possibly through shared neural pathways.

For patients, this research validates that their widespread pain symptoms are real and connected to their jaw condition, not separate unrelated problems.

55/100
Evidence StrengthModerate
Study Quality
Sample Size
Replication
88%
Had Pain in 4+ Body Regions
40
Different Pain Areas Identified
56%
Cervical Spine Involvement
70%
Right Masseter Pain

Results Comparison

Right Masseter Pain by Gender

%
Men92.3 %
Women62.2 %

Right TMJ Pain by Gender

%
Men84.6 %
Women43.2 %

Key Findings

Widespread pain patterns beyond the jawHigh

88% of patients reported pain in 4 or more body regions, with 40 different areas identified across all participants

High cervical spine involvementHigh

56% of patients had cervical spine pain, suggesting important anatomical connections between jaw and neck

Gender differences in masseter and TMJ painMedium

Men had significantly higher rates of right masseter (92.3% vs 62.2%) and right TMJ pain (84.6% vs 43.2%)

Body charts revealed complex pain patternsMedium

Patients used dots for localized pain and arrows for radiating pain, showing both focal and referred patterns

Most patients had manageable pain levelsMedium

60% had low-intensity pain with low disability, while only 10% had severe functional limitation

Study Methodology
Study Design
Cross-sectional observational study using standardized TMJ assessment and body chart pain mapping
Sample Size
50
Duration
Single assessment session
Population
Healthy adults with complete natural dentition and TMJ myofascial pain with referral
Outcome Measures
DC/TMD clinical examination · TMD Pain Screener · Graded Chronic Pain Scale v2.0 · Body chart pain drawings

Strengths

  • Used standardized DC/TMD diagnostic criteria
  • Comprehensive body chart assessment revealing widespread patterns
  • Clear documentation of pain distribution using visual mapping

Limitations

  • Small sample size (50 patients) limits generalizability
  • Cross-sectional design cannot establish causality
  • Self-reported pain locations may be subjective or incomplete
  • Single-center study with homogeneous young adult population

Key Takeaways for Patients

What This Means for You

  1. 01Jaw pain often involves multiple body areas beyond just your jaw joint and muscles
  2. 02Neck and shoulder pain commonly occur together with jaw problems
  3. 03Your widespread pain symptoms are real and connected to your jaw condition
  4. 04Treatment may need to address posture and neck issues, not just the jaw
  5. 05Body charts can help your healthcare team understand your complete pain pattern

Read the Full Paper

Access the complete peer-reviewed study from Frontiers in Neurology

View Full Study

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