Systematic ReviewTreatment: Manual TherapyClinical RelevanceDOI
4 min read
Jump to:

Patient-friendly summary

If you read nothing else

This review shows manual therapy can help with myofascial pain related to temporomandibular disorders, but more studies are needed.

Bottom line

Manual therapy might help with your jaw pain, worth discussing with a provider.

Preliminary evidence

Ask your provider

  • What type of manual therapy do you recommend for my jaw pain?
  • How many sessions will I need and how often?

Try this week

  • Ask your provider about manual therapy options for your jaw pain.

How well it works

5.0 / 10

Manual therapy was better than no treatment in some cases, but not always better than other treatments.

Preliminary

Study participants

n=27912 to 69not specified

patients with temporomandibular disorders

Full research — for clinicians and curious readers

Study Summary

Background

Myofascial pain in the masticatory (jaw) muscles is the most common form of temporomandibular disorder (TMD), affecting more than half of patients seen in specialized clinics worldwide. This condition causes significant pain and functional limitations, making it challenging for clinicians to treat due to its complex causes and the many different treatment approaches available. Manual therapy has emerged as a promising conservative treatment option, involving techniques like jaw mobilization, muscle massage, stretching exercises, and movement training. However, the scientific evidence for manual therapy's effectiveness has been limited by inconsistent study designs, varied treatment combinations, and lack of standardized diagnosis criteria.

What They Did

The researchers conducted a systematic review following strict scientific guidelines (PRISMA) to evaluate the effectiveness of manual therapy for TMD-related myofascial pain. They searched multiple medical databases for randomized controlled trials published through 2019, using specific search terms related to TMD, myofascial pain, and manual therapy. Only studies that used the Research Diagnostic Criteria for TMD (RDC/TMD) for diagnosis were included to ensure consistency. The researchers independently reviewed all studies and assessed their quality using the Cochrane Risk of Bias tool.

They analyzed 143 initial records, which were narrowed down to just 5 high-quality studies that met their strict criteria.

What They Found

The 5 included studies examined 279 patients total, with 156 receiving manual therapy either alone or combined with counseling. The studies showed that manual therapy was effective for pain relief in all cases evaluated. However, the results were mixed when compared to other treatments. In one study, manual therapy was better than no treatment at all.

In another study, manual therapy was more effective than counseling alone (P < 0.001). However, when manual therapy was combined with counseling, it was not statistically better than counseling alone (success rate of 77% vs 57%, P = 0.157). Manual therapy also showed no significant advantage over botulinum toxin injections for pain relief. One study found that professional manual therapy combined with home exercises was significantly more effective than home therapy alone for reducing both resting and stress-related pain (P < 0.001).

The benefits of manual therapy were maintained at follow-up periods ranging from 4 weeks to 1 year.

What This Means

This review provides important evidence that manual therapy is an effective, low-cost, and non-invasive treatment option for TMD-related myofascial pain. While it may not be superior to all other treatments, manual therapy offers several advantages including safety, reversibility, and cost-effectiveness compared to more expensive options like botulinum toxin injections. The research suggests that combining manual therapy with patient education and counseling may provide the best outcomes. However, the quality of available evidence is limited, with all studies showing some risk of bias and significant differences in treatment approaches.

Clinicians can confidently offer manual therapy as a first-line treatment for TMD-related jaw pain, particularly when combined with patient education. More high-quality research is needed to establish clearer guidelines for optimal treatment protocols and to compare long-term effectiveness against other treatment options.

58/100
Evidence StrengthModerate
Study Quality
Sample Size
Replication
5
Studies Included
279
Total Patients
77%
Success Rate (MT + Counseling)
P<0.001
MT vs Counseling Alone

Results Comparison

Pain Reduction Success Rate (%)

%
Manual Therapy + Counseling77 %
Counseling Only57 %

Key Findings

Manual therapy was effective for pain relief in all 5 studies evaluatedHigh

Consistent pain reduction across different study populations and treatment protocols

Manual therapy alone was superior to counseling aloneHigh

One study showed statistically significant improvement (P < 0.001) favoring manual therapy

No significant advantage over botulinum toxin injectionsMedium

Both treatments improved pain levels with similar effectiveness (P > 0.05)

Combined treatment may not be better than counseling aloneMedium

Manual therapy plus counseling (77% success) vs counseling only (57% success), P = 0.157

Professional manual therapy plus home exercises superior to home therapy aloneHigh

Significantly better for both resting and stress-related pain (P < 0.001)

All included studies had unclear or high risk of biasHigh

Methodological limitations limit strength of conclusions

Study Methodology
Study Design
Systematic review of randomized controlled trials
Sample Size
279
Duration
Studies followed patients from 4 weeks to 1 year
Population
Patients with TMD-related myofascial pain diagnosed by RDC/TMD criteria
Outcome Measures
Pain reduction success rates · VAS pain scores · Functional improvements · RDC/TMD criteria

Strengths

  • Used standardized diagnostic criteria (RDC/TMD) for consistency
  • Followed PRISMA guidelines for systematic review methodology
  • Included only randomized controlled trials
  • Independent review by multiple researchers to reduce bias

Limitations

  • Only 5 studies met inclusion criteria, limiting generalizability
  • All included studies had unclear or high risk of bias
  • Significant heterogeneity prevented meta-analysis
  • Small sample sizes in individual studies

Key Takeaways for Patients

What This Means for You

  1. 01Manual therapy is a safe and effective treatment option for jaw muscle pain related to TMD
  2. 02It works just as well as expensive treatments like Botox but costs much less and has fewer risks
  3. 03Combining manual therapy with education about self-care and home exercises may provide the best results
  4. 04Treatment benefits can last from weeks to a full year after completing therapy
  5. 05More research is needed to determine the best treatment protocols and long-term effectiveness

Read the Full Paper

Access the complete peer-reviewed study from Journal of Oral & Facial Pain and Headache

View Full Study

Related Research

●●●●○ StrongSystematic Review

Myofascial Release for Chronic Low Back Pain: A Systematic Review and Meta-Analysis

Wu et al.·Frontiers in Medicine·2021

This systematic review found that myofascial release significantly reduces pain and improves physical function in patients with chronic low back pain. However, it showed no benefits for quality of life, balance, or mental health outcomes.

Manual TherapyRead →
●●●●○ StrongNarrative Review

Do Self-Myofascial Release Devices Release Myofascia? Rolling Mechanisms: A Narrative Review

Behm, David G. & Wilke, Jan·Sports Medicine·2019

This narrative review challenges the popular term "self-myofascial release," finding insufficient evidence that foam rolling primarily works by mechanically releasing fascial restrictions. Instead, neural mechanisms including pain modulation, autonomic changes, and non-local reflex effects appear to drive the observed benefits in range of motion and pain reduction.

Manual TherapyRead →
●●●●○ StrongPilot Study

Compression at Myofascial Trigger Point on Chronic Neck Pain Provides Pain Relief through the Prefrontal Cortex and Autonomic Nervous System: A Pilot Study

Morikawa et al.·Frontiers in Neuroscience·2017

MTrP compression significantly reduced neck pain and decreased prefrontal cortex activity while shifting autonomic balance toward parasympathetic dominance. Changes in heart rate variability parameters correlated with both pain relief and prefrontal hemodynamic responses.

Manual TherapyRead →
●●●○○ ModerateRandomized Controlled Trial

Acute Effect of a Single Functional Neurology Intervention on Muscular Trigger Point

Rey-Mota et al.·Applied Sciences·2025

A single 10-minute functional neurology session increased pressure pain threshold by 46.4% in upper trapezius trigger points compared to no intervention. Thermography confirmed improved peripheral blood flow, suggesting this non-invasive brain-based approach may rapidly reduce myofascial pain sensitivity.

Manual TherapyRead →